The mission of EMNet’s Translation Research Unit is to leverage large clinical, biometrics, and omics data not only to delineate disease pathobiology (e.g., that of bronchiolitis and childhood asthma) but also to transform medical care in the U.S. and around the world. We take the vision-driven approach — rather than technology- or needs-driven approaches — to make quantum leaps in science. Our work applies novel transdisciplinary methods — an integration of epidemiology, causal inference, computational biology, and machine learning — to the complex interplay between host factors, environmental factors, and health outcomes.
For example, in MARC-35 and MARC-43, we apply systems biology approaches to integrate clinical and omics (e.g., genetics, epigenetics , transcriptomics, proteomics, metabolomics, and microbiomics) data to uncover the mechanisms that link severe bronchiolitis to childhood asthma.
For more information, please contact Dr. Kohei Hasegawa at khasegawa@mgh.harvard.edu.
Director: Kohei Hasegawa, MD, MPH, PhD
Faculty: Zhaozhong Zhu, ScD
Post-doctoral Fellows:
– Michihito Kyo, MD PhD
– Heidi Makrinioti, MD PhD
– Hideaki Miyachi, MD PhD
– Tadao Ooka, MD, PhD
– Ryohei Shibata, MD PhD
Consultant: Liming Liang, PhD (Harvard School of Public Health/MGH).