MARC

Multicenter Airway Research Collaboration

Overview

Multicenter Airway Research Collaboration (MARC) is an international research network focusing on respiratory/allergy emergencies such as asthma, COPD, anaphylaxis, bronchiolitis, and other similar disorders.

Two major research activities are MARC-35 and MARC-43, which are two multicenter cohorts on infants. The cohorts examine which children develop recurrent wheezing and asthma, and the relation of airway microbiome to risk of childhood asthma.
Major Research Themes
  • Asthma
  • COPD
  • Bronchiolitis
  • Anaphylaxis
  • Food allergy
  • Pneumonia
  • Smoking cessation
  • Inappropriate use of antibiotics
  • Pulmonary hypertension
  • Microbiome
  • Translational Research
MARC-35
(The WIND
Study)
MARC-43
(The CHIME
Study
ECHO
Translational
Research Unit


Past Initiatives

During the early months of the COVID-19 pandemic, the Human Epidemiology and Response to SARS-CoV-2 (HEROS) study examined the SARS-CoV-2 infection in households with children.

Click here to learn more about the HEROS Study

The 44th Multicenter Airway Research Collaboration (MARC-44) was a retrospective cohort study of the trends, health care utilization, and cost of anaphylaxis and other food-related acute allergic reactions in infants and toddlers who presenting for ED care in the US.

Click here to learn more about MARC-44.

The 41st Multicenter Airway Research Collaboration (MARC-41) built on the success of the MARC-36 and -37 studies by implementing an evidenced-based hospital-initiated care bundle and evaluating its effectiveness at five geographically-diverse US sites. 

Click here to learn more about MARC-41.

The 38th Multicenter Airway Research Collaboration (MARC-38) was a multicenter chart review study that investigated the characteristics, ED management, and post-ED care of 2,000 children and adults who presented to the ED with an acute allergic reaction to food or insect stings. Please contact Dr. Carlos Camargo if you would like additional details.

Primary publications:

  1. Clark S, Boggs KM, Balekian DS, Hasegawa K, Vo PT, Rowe BH, Camargo CA Jr. Changes in emergency department concordance with guidelines for the management of stinging insect-induced anaphylaxis: 1999-2001 vs 2013-2015. Ann Allergy Asthma Immunol 2018; 120: 419-423. PMID: 29407420
  2. Clark S, Boggs KM, Balekian DS, Hasegawa K, Vo P, Rowe BH, Camargo CA Jr. Changes in emergency department concordance with guidelines for the management of food-induced anaphylaxis: 1999-2001 versus 2013-2015. J Allergy Clin Immunol Pract 2019; in press. PMID: 30974210

The 42nd Multicenter Airway Research Collaboration (MARC-42) was an analysis of large administrative datasets and survey data to investigate chronic obstructive pulmonary disease (COPD) readmission rates and management.

Click here to learn more about MARC-42.

The 40th Multicenter Airway Research Collaboration (MARC-40) was a retrospective cohort study using data from the Research Patient Data Registry (RPDR) of adults hospitalized with acute exacerbation of chronic pulmonary obstructive disease (AECOPD). Please contact Dr. Kohei Hasegawa if you would like additional details.

The 39th Multicenter Airway Research Collaboration (MARC-39) was a multicenter, prospective observational study of adult ED patients with acute asthma. Please contact Dr. Kohei Hasegawa if you would like additional details.

Primary publication:
Goto T, Camargo CA Jr, Gimenez-Zapiola C, Pallin DJ, Shapiro NI, Ferro TJ, Rainville C, Stoyanov S, Hasegawa K. Comparing ran-out status of inhaled short-acting beta-agonists in emergency department patients with acute asthma: 1996-1998 versus 2015-2017. J Allergy Clin Immunol Pract 2018; 6: 1999-2005. PMID: 29653218

The 36th Multicenter Airway Research Collaboration (MARC-36) was a multicenter, chart review study of adult ED patients with acute asthma, with a survey about asthma centers affiliated with the study site. Please contact Dr. Carlos Camargo or Dr. Kohei Hasegawa if you would like additional details.

Primary Publication:
Hasegawa K, Sullivan AF, Tsugawa Y, Turner SJ, Massaro S, Clark S, Tsai CL, Camargo CA Jr. Comparison of US emergency department acute asthma care quality: 1997-2001 and 2011-2012. J Allergy Clin Immunol 2015; 135: 73-80. 25263233

The 30th Multicenter Airway Research Collaboration (MARC-30) was a multicenter, prospective cohort study of bronchiolitis admissions. Please contact Drs. Jonathan Mansbach or Carlos Camargo if you would like additional details.

Primary publication:
Mansbach JM, Piedra PA, Teach SJ, Zaoutis LB, Sullivan AF, Forgey T, Clark S, Espinola JA, Camargo CA Jr. Prospective, multicenter study of viral etiology and hospital length-of-stay in children with severe bronchiolitis. Arch Pediatr Adolesc Med. 22473882

Click here to listen to the author interview podcast with Dr. Jonathan Mansbach.

For information about other MARC studies, click here.